Article Text


Multicentric Castleman's disease associated with rheumatoid arthritis: a possible role of hepatitis B antigen.
  1. E Ben-Chetrit,
  2. D Flusser,
  3. E Okon,
  4. Z Ackerman,
  5. A Rubinow
  1. Department of Medicine A, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.


    A patient with seropositive rheumatoid arthritis and a carrier of hepatitis B surface antigen developed angiofollicular hyperplasia (multicentric Castleman's disease). The hepatitis B virus and the rheumatoid factor may have had a role in the aetiology of this lymphatic disorder. The development of Castleman's disease in association with these factors may provide another clue supporting the reactive nature of this disease.

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