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Immunohistological features of synovitis in ankylosing spondylitis: a comparison with rheumatoid arthritis.
  1. B L Kidd,
  2. K Moore,
  3. M T Walters,
  4. J L Smith,
  5. M I Cawley
  1. Rheumatology Unit, Southampton General Hospital.

    Abstract

    The immunohistological features of the synovial membrane in ankylosing spondylitis, HLA-B27 associated oligoarthritis, and rheumatoid arthritis wer examined with particular reference to T lymphocyte subsets. T helper (CD4+) cells clearly outnumbered T suppressor/cytotoxic (CD8+) cells in rheumatoid arthritis, whereas both cell types were present in equal numbers in ankylosing spondylitis. A reduction of CD4+/CD45R+ suppressor/inducer cells relative to CD4+/UCHL1+ helper/inducer cells was apparent in all diagnostic groups. The observations were suggestive of disease specific inflammatory responses within synovial membrane.

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