Article Text

PDF

A search for retrovirus infection in systemic lupus erythematosus and rheumatoid arthritis.
  1. B K Pelton,
  2. M North,
  3. R G Palmer,
  4. W Hylton,
  5. C Smith-Burchnell,
  6. A L Sinclair,
  7. M Malkovsky,
  8. A G Dalgleish,
  9. A M Denman
  1. Connective Tissue Diseases Research Group, Clinical Research Centre, Harrow, Middlesex.

    Abstract

    Evidence for retroviral infection in general and human immunodeficiency virus (HIV) infection in particular was sought in freshly isolated peripheral blood T cells, B cells, and monocyte-macrophages from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) and also in T cell and B cell lines established from the same source. Similar cells isolated from rheumatoid synovial membrane were also examined. The strategy used for the detection of virus was cocultivation with susceptible cell lines looking for syncytia formation, reverse transcriptase production, and nucleic acid hybridisation with HIV cDNA probes. No evidence for infection was obtained.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.