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Growth of human B cell colonies from peripheral blood of patients with systemic lupus erythematosus.
  1. A C Fay,
  2. S Price,
  3. A Trudgett,
  4. J D McCrea,
  5. M Haire,
  6. M W Boyd,
  7. T A McNeill

    Abstract

    Human B cell colonies were grown from peripheral blood of 12 patients with systemic lupus erythematosus (SLE) and from 12 healthy control subjects. The SLE group showed a large increase (p less than 0.001) in the number of colony forming cells (CFC) present in peripheral blood as compared with controls. The CFC were of the pre-B cell type. There was also a loss of OKT8+ cell inhibition of B cell colony growth in the SLE group compared with control subjects.

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