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The timing of prednisolone dosage and its effect on morning stiffness in rheumatoid arthritis.
  1. M De Silva,
  2. A Binder,
  3. B L Hazleman

    Abstract

    Forty-one patients with rheumatoid arthritis (RA) maintained on low dose prednisolone (mean 5.8 mg) participated in a double-blind cross-over study to determine the effect of timing (morning or night) of prednisolone dosage on morning stiffness. Prednisolone given at night resulted in a significantly shorter duration of morning stiffness (p = 0.0001) than did an equivalent dose given in the morning.

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