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Lymphoproliferative malignancy in rheumatoid arthritis: a study of 20 cases.
  1. D P Symmons,
  2. M Ahern,
  3. P A Bacon,
  4. C F Hawkins,
  5. P L Amlot,
  6. E L Jones,
  7. P Prior,
  8. D L Scott

    Abstract

    A series of 20 patients with definite or classical rheumatoid arthritis who subsequently developed a lymphoproliferative malignancy are described. The mean time between the onset of the 2 diseases was 13.2 years. A wide range of types of non-Hodgkin's lymphoma and Hodgkin's disease were found; there were no unusual histological features in the lymphomas. Although many of the patients had had gold, penicillamine, and other second-line drugs, none of them had received cytotoxic drugs, and there was no evidence that therapy was a cause of their malignancies. The likely cause of the association is a predisposition to both diseases.

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