Article Text


Prednisolone inhibits phagocytosis by polymorphonuclear leucocytes via steroid receptor mediated events
  1. Carolyn J. P. Jones,
  2. Karen J. Morris,
  3. Malcolm I. V. Jayson
  1. Rheumatic Diseases Centre, University of Manchester, Salford M6 8HD
  2. Hope Hospital, Salford M6 8HD


    Prednisolone, at concentrations between 2·78 × 10−6 M (1 μg/ml) and 1·39 × 10−8 M (5 × 10−3 μg/ml) exerts an inhibitory effect on the phagocytosis of latex particles by normal human polymorphonuclear leucocytes in vitro as assessed by electron microscopical analysis. This inhibition appears to be receptor-mediated, as it is dependent upon RNA and protein synthesis and is glucocorticoid specific.

    Statistics from

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.