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Prednisolone inhibits phagocytosis by polymorphonuclear leucocytes via steroid receptor mediated events
  1. Carolyn J. P. Jones,
  2. Karen J. Morris,
  3. Malcolm I. V. Jayson
  1. Rheumatic Diseases Centre, University of Manchester, Salford M6 8HD
  2. Hope Hospital, Salford M6 8HD

    Abstract

    Prednisolone, at concentrations between 2·78 × 10−6 M (1 μg/ml) and 1·39 × 10−8 M (5 × 10−3 μg/ml) exerts an inhibitory effect on the phagocytosis of latex particles by normal human polymorphonuclear leucocytes in vitro as assessed by electron microscopical analysis. This inhibition appears to be receptor-mediated, as it is dependent upon RNA and protein synthesis and is glucocorticoid specific.

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