Abstract

Prednisolone, at concentrations between 2·78 × 10⁻⁶ M (1 μg/ml) and 1·39 × 10⁻⁸ M (5 × 10⁻³ μg/ml) exerts an inhibitory effect on the phagocytosis of latex particles by normal human polymorphonuclear leucocytes in vitro as assessed by electron microscopical analysis. This inhibition appears to be receptor-mediated, as it is dependent upon RNA and protein synthesis and is glucocorticoid specific.