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Studies on autoantibodies to poly (adenosine diphosphate-ribose) in SLE and other autoimmune diseases.
  1. W J Morrow,
  2. D A Isenberg,
  3. H F Parry,
  4. L Shen,
  5. E E Okolie,
  6. F Farzaneh,
  7. S Shall,
  8. M L Snaith

    Abstract

    Sera from 41 patients with systemic lupus erythematosus (SLE), 87 controls with various diseases, and 30 normal subjects were examined for poly (adenosine diphosphate-ribose) and ds DNA binding. Elevated levels of poly (ADP-ribose) binding were found in 73% of the SLE patients compared with 58% who had raised ds DNA binding. In a further study of 160 sera from 27 patients with SLE, levels of antipoly (ADP-ribose) antibodies were shown to correlate with clinical activity better than either anti-ds DNA or ss DNA antibodies.

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