Article Text


Biochemical indices of response to hydroxychloroquine and sodium aurothiomalate in rheumatoid arthritis.
  1. J S Dixon,
  2. M E Pickup,
  3. H A Bird,
  4. M R Lee,
  5. V Wright,
  6. W W Downie


    Biochemical and clinical changes have been monitored in 30 patients with rheumatoid arthritis treated with either hydroxychloroquine or sodium aurothiomalate over a period of 6 months. Acute-phase reactants improved in both treatment groups, while serum sulphydryl and serum histidine improved only in the gold-treated patients. Correlation matrices were constructed from mean clinical and biochemical data at successive clinic visits. Correlations obtained with gold were more frequent and of a higher level of significance than those obtained with hydroxychloroquine at the doses we studied. This lends support to the use of correlation matrices as a screening test for potential long-term antirheumatoid activity of drugs in man.

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