Article Text

PDF

IgM-rheumatoid factors cross-reactive with IgG and a cell nuclear antigen: immunopathological implications?
  1. P M Johnson

    Abstract

    The cross-reaction of IgM-rheumatoid factors (IgM-RF) with a cell nuclear antigen has been further investigated by immunofluorescence procedures. This reaction appears to be optimal at pH 8-9, and fails to occur at pH 6.5. No evidence was obtained by immunofluorescence that IgM-RF bound to the cell nuclear antigen fixes complement. It would appear that the nuclear reactivity of IgM-RF may be of limited immunopathological significance, though this reaction is of note in understanding the behavioural nature of rheumatoid factors.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.