The effectiveness of a second intra-articular injection of yttrium-90 colloid was studied in 30 patients with persistent synovitis of the knee. All had responded poorly to a first injection of yttrium-90 yet seemed likely to benefit from this therapy. With a minimum review period of 6 months complete remission of synovitis was obtained in 20%, while 63% gained symptomatic relief, with some reduction of synovitis. No improvement occurred in 17%, and in this group generalised disease activity was more apparent.
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