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The effect of zinc on alkaline phosphatase activity in rheumatoid synovial tissue.
  1. J J Johnstone,
  2. L Bitensky,
  3. B Cashman,
  4. J Chayen

    Abstract

    To examine the reported beneficial effect of zinc in rheumatoid arthritis, rheumatoid synovial tissue has been maintained in vitro in non-proliferative culture with or without zinc sulphate in the culture medium. Alkaline phosphatase activity was measured by microdensitometry of the cytochemical reaction in cryostat sections; the activity in blood vessels was measured separately from that in the supporting tissue below the synovial surface. Zinc enhanced this activity optimally at concentrations of between 10(-5) and 10(-4) mol/l.

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