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Conference on Articular Cartilage
    1. The Biomechanics Unit, Imperial College of Science and Technology, London

    Abstract

    • Introduction

    • I. Structure of articular cartilage

      • Microscopical appearance and organization of articular cartilage surfaces

      • Scanning electron microscope study of normal human articular cartilage

      • Sequential changes in superficial defects in articular cartilage studied with the scanning electron microscope

      • Cartilage fibrillation versus ink-staining patterns: Scanning electron microscope study

      • Stain distribution with alcian blue in articular cartilage

    • I. Short communications

      • Some new morphological data on histogenesis of articular cartilage

      • Matrix structure in articular cartilage

      • Three-dimensional observations of articular cartilage matrix

      • Ultrastructural aspects of normal and osteoarthrotic cartilage

      • Scanning electron microscopy of human osteoarthrotic cartilage

    • II. Chemistry of the matrix

      • Structure and stability of proteoglycan aggregates

      • Structure of cartilage proteoglycans

      • Interaction of cartilage collagen fibrils and proteoglycans: Application of fluorescent labelling techniques for assay of enzymes degrading cartilage

      • Chain composition of pepsin-solubilized collagen from normal bovine and osteoarthrotic human articular cartilage

      • Passive agglutination method using collagen-coated tanned sheep erythrocytes to demonstrate collagen-glycosaminoglycan interaction

    • II. Short communications

      • Procollagen of chick xyphoid cartilage

      • Nature and location of crosslinks in cartilage collagen

      • Discontinuous nature of the protein-keratan sulphate core of cartilage proteoglycan

      • Concentration, distribution, and metabolism of glycosaminoglycans in different layers of normal human articular cartilage

      • Variations in glycosaminoglycans with surface site in human knee joint cartilage

      • Charged group behaviour in cartilage proteoglycans in relation to pH

      • Equilibria of calcium and phosphate ions in human articular cartilage

    • III. Metabolism

      • Nucleotide sugar metabolism in glycosaminoglycan biosynthesis

      • Biosynthesis of proteoglycans in cartilage

      • Cartilage turnover

    • III. Short communications

      • Effect of in vitro incubation on distribution and synthesis of glycosaminoglycans of articular cartilage

      • Effect of antiproteoglycan serum and Hyaluronidase on metabolic functions of calf cartilage cells in vitro

      • Overlabelling of chondroitin sulphate (ChS) chains after application of specific inhibitors of their biosynthesis

      • Synthesis of cerebroside sulphatides in human articular cartilage

      • Circadian rhythms in the excretion of urinary acid glycosaminoglycans

    • IV. Enzymes and degradation

      • Enzymes involved in degradation of cartilage in osteoarthrosis

      • Breakdown of protein-polysaccharide complexes by cartilage proteases

      • The possible function of lysozyme in cartilage metabolism

    • IV. Short communications

      • Evidence for secretion of a proteolytic enzyme from rheumatoid pannus and synovium

      • Action of rheumatoid synovial collagenase on cartilage collagen

      • Mechanism of cartilage and synovial fluid hyaluronate degradation by polysaccharidases

      • Response of articular cartilage in organ culture to growth hormone

      • Release and degradation of sulphated proteoglycans and collagen from the cell layer of human chondrocytes

      • Studies on cartilage vascularization

    • V.A. Functional properties

      • Fluid transport in cartilage

      • Fundamental fluid transport mechanisms through articular cartilage

      • An approximate equation for weeping lubrication, solved with an electrical analogue

      • Purification and properties of articular lubricant

      • An overall view of synovial joint lubrication

    • V.A. Short communications

      • Proteins associated with hyaluronic acid

      • Formation of lubricating monolayers at the cartilage surface

      • Lubrication defect of immobilized connective tissue matrices: Study of the biomechanical and biochemical characteristics of normal and immobilized rabbit knee

    • V.B. Functional properties

      • Some aspects of the mechanical behaviour of articular cartilage

      • In vitro fatigue testing of articular cartilage

      • Mechanical properties of articular cartilage and their relationship to matrix degradation and age

      • Contact pressures in the loaded cadaver human hip

    • V.B. Short communications

      • A simple mechanical model of articular cartilage

      • A new approach to the determination of the elastic modulus of articular cartilage

      • Wear properties of articular cartilage

      • Load bearing function of the menisci of the knee joint

    • VI. Pathogenesis of osteoarthrosis

      • Pathogenesis of osteoarthrosis: An hypothesis

      • Articular cartilage lesions in the Liverpool population

      • Contribution to the study of the initial stage of cartilage degeneration

      • Bone density in osteoarthrosis

      • Mechanical factors in the aetiology of osteoarthrosis

    • VI. Short communications

      • Histological changes in osteoarthrotic femoral head cartilage

      • Cartilage of the patella and its degeneration: Topographical variation of the glycosaminoglycan content

      • Ultrastructural and histological studies on articular cartilage in experimental osteoarthrosis

      • Proteoglycan aggregation in early experimental osteoarthrosis

      • Experimentally-induced osteoarthrosis in the dog: Collagen biosynthesis in control and fibrillated articular cartilage

      • Experimental evidence for an injury threshold for articular cartilage

      • Early loss of glycosaminoglycans in experimental haemarthrosis in dogs

      • Osteocyte death in rheumatic diseases

      • Differentiation and maintenance of articular (secondary) cartilage on avian membrane bones

      • Immunocytochemical and historical studies of a reversible transformation of chondrocytes in degraded cartilage matrix to a fibroblast-like morphology

    • Conclusions of a working party of morbid anatomists

    • Bibliography

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