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Research Article
Antinative DNA antibodies as a reaction to pyrazole drugs.
  1. M F Grayson,
  2. V M Martin,
  3. R L Markham

    Abstract

    A case history is presented of the occurrence of a high binding capacity for native DNA in the serum of a patient on phenylbutazone. This reverted to normal on stopping the drug. The patient also had a reversible neutropenia and leucopenia, and it is suggested that the high anti-DNA binding capacity was a feature of a drug-induced lupus-like phenomenon.

    https://doi.org/10.1136/ard.34.4.373

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