Are there gender differences in the severity of ankylosing spondylitis: results from the PSOAS cohort

Wonuk Lee ¹, John D Reveille ², John C Davis, Jr³, Thomas J Learch ⁴, Michael M Ward ⁵ and Michael H Weisman ^1*

¹ Cedars-Sinai Medical Center, United States
² University Texas, United States
³ UCSF, United States
⁴ University of Southern California, United States
⁵ National Institutes of Health, United States

^* To whom correspondence should be addressed. E-mail: weisman{at}cshs.org.

Accepted 2 November 2006

Abstract

Objective: To understand the influence of gender in determining the severity of ankylosing spondylitis (AS), we examined clinical and radiographic features in men and women in the PSOAS cohort, a large well-defined cross-sectional study of patients with AS.

Methods: Extensive clinical assessments as well as spineand pelvic radiographs were performed in 302 men and 100 women with AS of ¡ 20 years duration. Radiographs were scored using the Bath AS Radiographic Index Spine Score (BASRI-spine; range 2-12). Functional impairment was measured by the Bath Ankylosing Spondylitis Functional Index (BASFI) and the Health Assessment Questionnaire for the Spondyloarthropathies (HAQ-S).

Results: Radiographic severity was worse among men. The unadjusted median BASRI-spine score for men was 10 compared to 6.5 for women (P < 0.0001). Functional disability, as measured by the BASFI and HAQ- S, was not different between men and women. However, after adjusting for radiographic spinal damage, women were found to report worse functioning than men at any given level of radiographic damage. Women had a slightly earlier age of disease onset (21.5 vs. 23.6 yrs.) ; however, disease duration was identical in both groups (31.5 vs. 32.0 yrs.). Women more frequently reported family histories of AS in first degree relatives and were more likely to be treated with intra-articular steroids, sulfasalazine, and prednisone.

Conclusions: Among patients with longstanding AS, men have more severe radiographic changes; findings of treatment differences suggest that women may have more peripheral arthritis. At any given level of radiographic damage, self-reported functional limitations were worse among women.

Keywords: PSOAS cohort, ankylosing spondylitis, gender, radiographic changes, severity

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• BOONEN, A., CRUYSSEN, B. v., de VLAM, K., STEINFELD, S., RIBBENS, C., LENAERTS, J., Van den BOSCH, F., MIELANTS, H., DEWULF, L., VASTESAEGER, N. (2009). Spinal Radiographic Changes in Ankylosing Spondylitis: Association with Clinical Characteristics and Functional Outcome. The Journal of Rheumatology 36: 1249-1255 [Abstract] [Full Text]  
• Pradeep, D. J., Keat, A., Gaffney, K. (2008). Predicting outcome in ankylosing spondylitis. Rheumatology (Oxford) 47: 942-945 [Full Text]  
• Gensler, L S, Ward, M M, Reveille, J D, Learch, T J, Weisman, M H, Davis, J C Jr (2008). Clinical, radiographic and functional differences between juvenile-onset and adult onset ankylosing spondylitis: results from the PSOAS cohort. Ann Rheum Dis 67: 233-237 [Abstract] [Full Text]