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Extended Report |
1 Cedars-Sinai Medical Center, United States
2 University Texas, United States
3 UCSF, United States
4 University of Southern California, United States
5 National Institutes of Health, United States
* To whom correspondence should be addressed. E-mail: weisman{at}cshs.org.
Accepted 2 November 2006
| Abstract |
|---|
Objective: To understand the influence of gender in determining the severity of ankylosing spondylitis (AS), we examined clinical and radiographic features in men and women in the PSOAS cohort, a large well-defined cross-sectional study of patients with AS.
Methods: Extensive clinical assessments as well
as spineand pelvic radiographs were performed in 302 men
and 100 women with AS of ¡
20 years duration.
Radiographs were scored using the Bath AS Radiographic
Index Spine Score (BASRI-spine; range 2-12). Functional
impairment was measured by the Bath Ankylosing
Spondylitis Functional Index (BASFI) and the Health
Assessment Questionnaire for the Spondyloarthropathies
(HAQ-S).
Results: Radiographic severity was worse among men. The unadjusted median BASRI-spine score for men was 10 compared to 6.5 for women (P < 0.0001). Functional disability, as measured by the BASFI and HAQ- S, was not different between men and women. However, after adjusting for radiographic spinal damage, women were found to report worse functioning than men at any given level of radiographic damage. Women had a slightly earlier age of disease onset (21.5 vs. 23.6 yrs.) ; however, disease duration was identical in both groups (31.5 vs. 32.0 yrs.). Women more frequently reported family histories of AS in first degree relatives and were more likely to be treated with intra-articular steroids, sulfasalazine, and prednisone.
Conclusions: Among patients with longstanding AS, men have more severe radiographic changes; findings of treatment differences suggest that women may have more peripheral arthritis. At any given level of radiographic damage, self-reported functional limitations were worse among women.
Keywords: PSOAS cohort, ankylosing spondylitis, gender, radiographic changes, severity
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