Experience with experimental biological treatment and local gene therapy of Sjogren's syndrome: implications for exocrine pathogenesis and treatment

doi:10.1136/ard.2006.052761

The most recent version of this article was published on 1 November 2006

Ann Rheum Dis. Published Online First: 31 July 2006. doi:10.1136/ard.2006.052761

Review Article

Experience with experimental biological treatment and local gene therapy of Sjögren's syndrome: implications for exocrine pathogenesis and treatment

Beatrijs M. Lodde ¹^*, Bruce J. Baum ², PP Tak ³ and Gabor Illei ²

¹ NIH, AMC Amsterdam, United States
² NIH, United States
³ AMC Amsterdam, Netherlands

^* To whom correspondence should be addressed. E-mail: blodde{at}mail.nih.gov.

Accepted 22 July 2006

Abstract

Sjögren’s syndrome (SS) is an autoimmune exocrinopathy,mainly affecting lacrimal and salivary glands and resultingin ocular and oral dryness (keratoconjunctivitis sicca and xerostomia).The etiology and pathogenesis are largely unknown and only palliativetreatment is currently available. Data obtained from experimentalanimal and human studies employing biological agents or genetherapeutics can offer insight into the SS disease process.Here, we review the current literature on these approaches andassess the lessons learned about the SS pathogenesis.

Keywords: Sj�gren's syndrome, biological agents, exocrine gland, gene therapeutics, pathogenesis

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