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  • Response to: ‘The autoantibody repertoire in periodontitis: a role in the induction of autoimmunity to citrullinated proteins in rheumatoid arthritis? Antibodies against uncitrullinated peptides seem to occur prior to the antibodies to the corresponding …

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Correspondence response
Response to: ‘The autoantibody repertoire in periodontitis: a role in the induction of autoimmunity to citrullinated proteins in rheumatoid arthritis? Antibodies against uncitrullinated peptides seem to occur prior to the antibodies to the corresponding citrullinated peptides’ by Brink et al
  1. Paola de Pablo1,
  2. Thomas Dietrich2,
  3. Iain L C Chapple3,
  4. Michael Milward3,
  5. Christopher D Buckley1,
  6. Patrick J Venables4
  1. 1Rheumatology Research Group, School of Immunity & Infection, College of Medical & Dental Sciences, University of Birmingham, Birmingham, UK
  2. 2Department of Oral Surgery, School of Dentistry, College of Medical & Dental Sciences, University of Birmingham, Birmingham, UK
  3. 3Department of Periodontology, School of Dentistry, College of Medical & Dental Sciences, University of Birmingham, Birmingham, UK
  4. 4Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences, Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK
  1. Correspondence to Dr Paola de Pablo, Rheumatology Research Group, School of Immunity & Infection, College of Medical & Dental Sciences, University of Birmingham, Birmingham B15 2WB, UK; p.depablo{at}bham.ac.uk

https://doi.org/10.1136/annrheumdis-2014-205519

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    We would like to thank Brink et al1 for their interest in our paper. The authors reported that antibodies against arginine-containing peptides from rheumatoid arthritis (RA) autoantigens were present in a population-based sample of 386 individuals with pre-RA. These pre-dated the corresponding antibodies against citrullinated peptides which appeared closer to onset of symptoms.

    These results are in line with our results, …

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    Footnotes

    • Contributors All authors were involved in drafting the article or revising it critically for important intellectual content, and all authors approved the final version.

    • Funding This work was supported by ‘Gums & Joints’, a European Union FP7 Grant FP7 HEALTH-F2-2010-261460 and ‘RAPID’, a European Union funded ITN project 290246.

    • Competing interests None.

    • Provenance and peer review Commissioned; internally peer reviewed.

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