Abstracts
P1. Immunoablation with t cell depleted autologous peripheral blood stem cell rescue produces complete remission in thrombocytopenic purpura (TTP) recidivant and refractory to standard treatment
I. Espigado, J. Rodríguez, M. Carmona, D. Alonso, E. Ríos, J. Pérez-Hurtado, M. Martino, P. Noguerol, M. Vinuesa, R. Parody. Seville, Spain
| The first 150 words of the full text of this article appear below. |
Background: TTP is a life threatening uncommon condition. Immune mechanisms may play a part in its pathogenesis. First line treatment is based on plasma exchange, and roughly 85% of cases respond. Refractory and resistant/recidivant forms usually have a poor prognosis despite the association of alternative treatments. There is increasing evidence of the efficacy of high dose immunosuppression treatment in diseases with possible autoimmune pathogenesis.
Patient and methods: In April 1998 a 38 year
old woman was diagnosed with severe TTP. She was treated with intensive plasma exchange, achieving complete remission. While she was on a
plasmapheresis programme, the disease showed a recidivant and progressive course and became refractory to plasmatic exchange. It was
also resistant to steroids, intravenous immunoglobulin, vincristine,
and splenectomy. After written informed consent, treatment with
cyclophosphamide was started 1 g/m2 × 5 doses and a sixth
dose of 3 g/m2 followed by G-CSF (10 µg/kg/day × 7 days) to mobilise haemopoietic progenitor cells. Three cytapheresis
procedures were
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
Services
- Email this link to a friend
- Similar articles in this journal
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
