IL23R and IL12B genes: susceptibility analysis in rheumatoid arthritis
1 Immunology Department, Hospital Clínico San Carlos, Madrid, Spain
2 Rheumatology Department, Hospital Clínico San Carlos, Madrid, Spain
Correspondence to:
Dr J Varadé, Immunology Department, Hospital Universitario Clínico San Carlos, Prof Martin Lagos s/n, 28040 Madrid, Spain; gezabelvarade@gmail.com
Accepted 29 September 2008
| The first 150 words of the full text of this article appear below. |
The identification of additional genetic risk factors is an ongoing process that will aid in the understanding of rheumatoid arthritis (RA) aetiology. A genome-wide association scan in Crohn’s disease highlighted the IL23R gene as a susceptibility factor.1 The IL-23 receptor is a heterodimer formed by the products of two different genes: IL23R and IL12RB. Our aim was to analyse whether polymorphisms within the genes coding for the specific chain of the IL-23 receptor (IL23R) and for its p40 ligand (IL12B) and interacting in psoriasis2 are also associated with an altered risk of RA.
In agreement with previously published data,3–6 no statistically significant association was found with the IL12B polymorphisms (table 1).
|
View this table: Table 1 Association of IL23R (rs7517847 and rs11209026) and IL12B (rs6887695 and rs322227) SNP with RA
|
The minor alleles of the IL23R polymorphisms were associated with increased predisposition to RA (table 1).
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Google Scholar
PubMed
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
