Decreased plasma IL22 levels, but not increased IL17 and IL23 levels, correlate with disease activity in patients with systemic lupus erythematosus
1 Department of Respiratory Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China
2 Department of Rheumatology and Immunology, Changzheng Hospital, Second Military Medical University, Shanghai, China
3 Department of Cardiovascular Diseases, Changhai Hospital, Second Military Medical University, Shanghai, China
Correspondence to:
Dr Q Li, Department of Respiratory Medicine, Changhai Hospital, 168 Changhai Road, Shanghai 200433, China; liqressh@yahoo.com.cn
Accepted 26 July 2008
| The first 150 words of the full text of this article appear below. |
Interleukin 17 (IL17)-producing T helper (Th17) cells, a new effector T cell subset, appear to play an essential role in autoimmune diseases.1 It has been shown that IL22 is another Th17 cytokine in mice and IL23 is critical for Th17 development.2–5 Increased plasma IL17 levels have been reported in systemic lupus erythematosus (SLE).6 We analysed Th17-related cytokine profiles in the plasma of patients with SLE.
A total of 45 patients with SLE were studied. All patients received glucocorticoids (2.5–50 mg/day). There were 24 patients with active (SLE Disease Activity Index (SLEDAI) score of 
6; 22 female; mean (SD) age 37.3 (12.1)) and 21 with inactive disease (20 female; mean age 37.6 (11.8)). A total of 32 healthy subjects (30 female; mean age 38.3 (14.3)) were used as controls. Plasma samples were obtained under local ethics committee approved protocols and with informed consent. IL17, IL22 and IL23 levels were measured by
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
eLetters:
Read all eLetters
- Decreased plasma IL22 levels, but not increased IL17 and IL23 levels, correlate with disease activit
- Hai-Feng Pan, et al.
- Ann Rheum Dis Online, 23 Mar 2009 [Full text]
- Full Text
- Full Text (PDF)
- Submit a response
- Read responses to this article
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
