EDITORIAL
Periarticular bone changes in rheumatoid arthritis: pathophysiological implications and clinical utility
Departments of Orthopedics and Rheumatology, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, USA
Correspondence to:
Steven R Goldring, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA; goldrings@hss.edu
Accepted 16 November 2008
| The first 150 words of the full text of this article appear below. |
In recent decades there has been a dramatic change in the treatment approaches for management of rheumatoid arthritis (RA). The introduction of methotrexate and the subsequent development of the biological agents that target tumour necrosis factor (TNF) and/or immune cell activation pathways have dramatically improved patient outcomes. Nevertheless, as additional information becomes available from prospective studies of patients receiving these therapies, there is evidence that a significant number of individuals continue to experience progressive joint damage and functional impairment.1–6 Based on these observations, there is a need to develop validated assessment tools for identifying patients who are at risk for a poor prognosis and to target this population for more aggressive and/or specific therapies to prevent eventual joint damage. In this and a recent issue of the Annals of Rheumatic Diseases, two independent groups of investigators have utilised the techniques of bone mineral density (BMD) and radiographic analysis to
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Ann Rheum Dis 2009 68: 324-329.[Abstract] [Full Text] [PDF]
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