Investigation of association of genes NAT9, SLC9A3R1 and RAPTOR on chromosome 17q25 with psoriatic arthritis
ARC-Epidemiology Unit, University of Manchester, Manchester, UK
Correspondence to:
C E Filer, ARC-EU, Stopford Building, University of Manchester, Oxford Road, Manchester, M13 9PT, UK; charliefiler@doctors.org.uk
Accepted 24 March 2008
| The first 150 words of the full text of this article appear below. |
Psoriatic arthritis (PsA) is defined as "an inflammatory arthritis associated with psoriasis that is usually negative for rheumatoid factor".1 A strong genetic component to disease aetiology is suggested by the sibling recurrence risk (
s), which has been estimated to be between 27–55 and is higher than that for psoriasis alone (s 
4), suggesting an even stronger genetic component to disease.1–3 Previous work has implicated the human leukocyte antigen (HLA) region in conferring susceptibility to PsA. For example, several reports have found higher frequencies of the HLA B locus alleles, including HLA B27, in PsA participants compared to controls or patients with psoriasis.4 However, a recent study in a UK population did not show any contribution of HLA DRB1 or HLA Cw6, the major susceptibility variants for rheumatoid arthritis and psoriasis, respectively to PsA itself.5
Analysis in psoriasis families has identified a locus at chromosome 17q25 that shows evidence
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