Interleukin 11 and paired immunoglobulin-like type 2 receptor expression correlates with the number of joints with active arthritis in systemic juvenile idiopathic arthritis

T Mima¹, S Ishikawa¹, C Aoki¹, N Yoshio-Hoshino¹, Y Adachi¹, T Imagawa², M Mori², M Tomiita³, N Iwata⁴, T Murata⁵, M Miyoshi⁶, S Takei⁷, Y Aihara⁸, S Yokota², K Matsubara⁹, N Nishimoto¹

¹ Laboratory of Immune Regulation, Graduate School of Frontier Bioscience, Osaka University, Suita, Japan
² Department of Pediatrics, Yokohama City University School of Medicine, Yokohama, Japan
³ Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan
⁴ Aichi Children’s Health and Medical Center, Daifu, Japan
⁵ Department of Pediatrics, Osaka Medical College, Takatsuki, Japan
⁶ Kobe Children’s Hospital, Kobe, Japan
⁷ Department of Pediatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
⁸ Children’s Medical Center, Yokohama City University Medical Center, Yokohama, Japan
⁹ DNA Chip Research Inc., Yokohama, Japan

Correspondence to:
N Nishimoto, Laboratory of Immune Regulation, Graduate School of Frontier Bioscience, Osaka University, 1-3, Yamada-Oka, Suita-City, Osaka 565-0871, Japan; norihiro@fbs.osaka-u.ac.jp

Accepted 22 May 2008

The first 150 words of the full text of this article appear below.

Systemic juvenile idiopathic arthritis (sJIA) is characterised by systemic inflammatory symptoms such as spiking fever, skin rash, pericarditis and hepatosplenomegaly, along with arthritis.¹ We reported the abnormal expression of genes involved in cytokine networks and mitochondrial function in patients with sJIA identified by DNA microarray.² The current study was performed to extend these results.

To identify genes that correlate with arthritis severity or systemic inflammation in patients with sJIA, we further analysed the 3491 genes identified by prior microarray analysis to be abnormally expressed in the peripheral blood of 51 patients with sJIA.² They all fulfilled International League of Associations for Rheumatology (ILAR) criteria.³ Of these genes, 2267 were annotated in the Expression Analysis Systematic Explorer system (EASE) V. 2.0.⁴ The statistical correlation between the expression level of each gene, the number of joints with active arthritis (median: 4, range: 0–39) and the serum level of C-reactive protein (CRP) (median: . . . [Full text of this article]

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