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Annals of the Rheumatic Diseases 2009;68:152-153; doi:10.1136/ard.2007.078907
Copyright © 2009 BMJ Publishing Group Ltd & European League Against Rheumatism.

Subluxing arthropathy: an unusual manifestation of the antisynthetase syndrome

O Meyer1, H Charlanne2, P Cherin3, Y Allanore4, P Coquerelle5, B Grardel6, A-M Chamot7, E Hachulla2 on behalf of The Club Rhumatismes Et Inflammation

1 Department of Rheumatology, D. Diderot University, Bichat Teaching Hospital, AP-HP, Paris, France
2 Department of Internal Medicine, Claude Huriez Teaching Hospital, Lille, France
3 Department of Internal Medicine, Pitié-Salpêtrière Teaching Hospital, AP-HP, Paris, France
4 Department of Rheumatology A, Paris Descartes University, Cochin Teaching Hospital, AP-HP, Paris, France
5 Department of Rheumatology, Germon and Gauthier Hospital, Béthune, France
6 Rheumatology Private Practice, Arras, France
7 Rheumatology Private Practice, Morges, Switzerland

Correspondence to:
Professor Olivier Meyer, Department of Rheumatology, CHU Bichat, 46 rue Henri Huchard, 75018 Paris France; olivier.meyer@bch.aphp.fr

Accepted 28 January 2008

The first 150 words of the full text of this article appear below.

Antisynthetase syndrome was first described by Marguerie et al as a combination of polymyositis (or at least creatine kinase elevation), diffuse interstitial lung disease and autoantibodies to t-RNA synthetase.1

Joint signs and symptoms occur in up to 90% of patients with polymyositis or dermatomyositis2 and/or antisynthetase syndrome, occasionally as the initial manifestations. They include arthralgia, polyarthritis and deforming arthropathy with subluxation.

To establish a multicentre registry of patients with joint manifestations of antisynthetase syndrome, a standardised form was posted on the CRI (Club Rhumatismes et Inflammation) website (http://www.cri-net.com), which is part of the French Society for Rheumatology, with the partnership of the French Society of Internal Medicine.

During a 12-month study period, 40 cases of antisynthetase syndrome were identified. There were 31 women and nine men with a mean age of 46.5 (SD 12.6) years at the diagnosis of polyarthritis or polyarthralgia. Published classification criteria for a second . . . [Full text of this article]


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This article has been cited by other articles:

  • NAGASHIMA, T., SATO, H., MINOTA, S. (2009). Destructive Arthropathy Associated with Dermatomyositis Sine Myositis Positive for Anti-Jo-1 and Anti-Cyclic Citrullinated Peptide Antibodies. The Journal of Rheumatology 36: 2133-2134 [Full Text]  

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