Subluxing arthropathy: an unusual manifestation of the antisynthetase syndrome
1 Department of Rheumatology, D. Diderot University, Bichat Teaching Hospital, AP-HP, Paris, France
2 Department of Internal Medicine, Claude Huriez Teaching Hospital, Lille, France
3 Department of Internal Medicine, Pitié-Salpêtrière Teaching Hospital, AP-HP, Paris, France
4 Department of Rheumatology A, Paris Descartes University, Cochin Teaching Hospital, AP-HP, Paris, France
5 Department of Rheumatology, Germon and Gauthier Hospital, Béthune, France
6 Rheumatology Private Practice, Arras, France
7 Rheumatology Private Practice, Morges, Switzerland
Correspondence to:
Professor Olivier Meyer, Department of Rheumatology, CHU Bichat, 46 rue Henri Huchard, 75018 Paris France; olivier.meyer@bch.aphp.fr
Accepted 28 January 2008
| The first 150 words of the full text of this article appear below. |
Antisynthetase syndrome was first described by Marguerie et al as a combination of polymyositis (or at least creatine kinase elevation), diffuse interstitial lung disease and autoantibodies to t-RNA synthetase.1
Joint signs and symptoms occur in up to 90% of patients with polymyositis or dermatomyositis2 and/or antisynthetase syndrome, occasionally as the initial manifestations. They include arthralgia, polyarthritis and deforming arthropathy with subluxation.
To establish a multicentre registry of patients with joint manifestations of antisynthetase syndrome, a standardised form was posted on the CRI (Club Rhumatismes et Inflammation) website (http://www.cri-net.com), which is part of the French Society for Rheumatology, with the partnership of the French Society of Internal Medicine.
During a 12-month study period, 40 cases of antisynthetase syndrome were identified. There were 31 women and nine men with a mean age of 46.5 (SD 12.6) years at the diagnosis of polyarthritis or polyarthralgia. Published classification criteria for a second
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