EDITORIAL
Anakinra treatment for systemic juvenile idiopathic arthritis and adult onset Still disease
Paediatric and Adolescent Rheumatology Department of Immunology and Molecular Pathology, University College London, London, UK
Correspondence to:
Professor Patricia Woo, University College London, Paediatric and Adolescent Rheumatology Department of Immunology and Molecular Pathology 46, Cleveland Street London, W1T 4JF UK; patricia.woo@ucl.ac.uk
Accepted 3 January 2008
| The first 150 words of the full text of this article appear below. |
Systemic juvenile idiopathic arthritis (sJIA) is a distinct clinical spectrum of illnesses compared to other types of chronic arthritides in children. Typically, the clinical features include the characteristic quotidian fevers, evanescent rashes, serositis, lymphadenopathy and hepatosplenomegaly in addition to persistent and destructive arthritis at the severe end of the spectrum. The children also appear to be more prone to macrophage activation syndrome/secondary histiolymphocytic haemophagocytosis (HLH). It is generally acknowledged that a similar disease occurs rarely in adults: adult onset Still disease (AOSD). However, the clinical classifications for each were developed separately and are different from each other. The Yamaguchi AOSD criteria1 are less precise in the exclusions and are able to include a wider spectrum of clinical manifestations as compared to the International League of Associations for Rheumatology (ILAR) classification of sJIA.2
The pathogenesis of sJIA is still the subject of much research and the first reports of the role
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