A polymorphism in the gene encoding the Fc
IIIA receptor is a possible genetic marker to predict the primary response to infliximab in Japanese patients with rheumatoid arthritis
Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
Correspondence to:
Katsunori Ikari, MD, PhD, Institute of Rheumatology, Tokyo Women’s Medical University, 10–22 Kawada, Shinjuku, Tokyo 162-0054, Japan; kikari@ior.twmu.ac.jp
Accepted 8 March 2008
| The first 150 words of the full text of this article appear below. |
The prediction of treatment outcome of patients with rheumatoid arthritis (RA) may avoid wasting time and cost of treatment, and allow better targeting of aggressive treatment. Recently, an amino acid-changing polymorphism in the gene encoding the Fc
IIIA receptor (FcRIIIA), valine (V)/phenylalanine (F) (rs396991), was found to be associated with increased likelihood of response to tumour necrosis factor (TNF)-
inhibitors in the treatment of RA.1 The aim of the present study was to determine whether this FcRIIIA V/F polymorphism is associated with treatment outcome of infliximab (the first TNF- inhibitor approved in Japan) in Japanese patients with RA.
The study was approved by the Tokyo Women’s Medical University Genome Ethics Committee. The basis of this study was the collection of prospective clinical data from Japanese patients with RA who had received infliximab. The diagnosis of RA was established using the American College of Rheumatology 1987 revised classification
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