Increased blood glucose levels following intra-articular injection of methylprednisolone acetate in patients with controlled diabetes and symptomatic osteoarthritis of the knee

G S Habib¹, M Bashir², A Jabbour³

¹ Rheumatology Clinic, Nazareth Hospital, Nazareth, and Department of Medicine, Carmel Medical Center, Haifa, Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
² Department of Medicine, Carmel Medical Center, Haifa, Israel
³ Central Lab, Nazareth Hospital, Nazareth

Correspondence to:
G S Habib, Rheumatology Clinic, Nazareth Hospital, P.O. Box 11, Nazareth 16100, Israel; gshabib62@yahoo.com

Accepted 9 April 2008

The first 150 words of the full text of this article appear below.

The effect of oral or intravenous steroid treatment on glucose metabolism is well known.¹ Intra-articular steroid injection (IASI) at the knee joint is a common procedure,² however there are no studies on the effect of IASI on glucose metabolism. Patients with controlled diabetes (HgA1C<7), using modern versions of blood glucose monitoring devices, with knee pain due to osteoarthritis of the knee (OAK) for more than 3 months without sufficient response to non-steroidal anti-inflammatory drugs (NSAIDs) and physical therapy were offered an IASI of 50 mg of methylprednisolone acetate (MPA) (Pharmacia & Upjohn, Puurs, Belgium) at the knee joint. If they agreed, patients were asked to monitor their blood glucose levels before and 2 h after breakfast, lunch and supper every other day for 1 week prior to injection and daily for 4 days, then every other day for 10 days following the injection using the same glucose monitoring devices. All . . . [Full text of this article]

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