Duration of pre-rheumatoid arthritis anti-cyclic citrullinated peptide positivity is positively associated with age at seroconversion
1 Jan van Breemen Institute, Amsterdam, The Netherlands
2 VU University Medical Center, Department of Rheumatology, Amsterdam, The Netherlands
Correspondence to:
Dr D van Schaardenburg, Department of Rheumatology, Jan van Breemen Institute, 1056 AB Amsterdam, The Netherlands; d.v.schaardenburg@janvanbreemen.nl
Accepted 28 January 2008
| The first 150 words of the full text of this article appear below. |
Majka et al1 have recently shown that higher age at the time of diagnosis of rheumatoid arthritis (RA) is associated with an increased period of prediagnosis antibody positivity for rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP). We have extended this observation using a previously described RA cohort (n = 79) in which serial preclinical serum samples were available, in most cases preceding and following seroconversion, thereby enabling approximation of the age at seroconversion.2 A total of 32 patients were anti-CCP positive and 22 patients were IgM-RF positive in the preclinical period. The age at seroconversion and the period of seropositivity before onset of RA symptoms was calculated using the mean of the time points of the last seronegative and the first seropositive sample. When samples preceding seropositivity were unavailable (anti-CCP for six patients; IgM-RF for three patients), the date of the first available sample was used. Patients positive for
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