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Abstracts

001 ENDOTHELIAL DYSFUNCTION AND MYOCARDIAL REMODELLING IN PATIENTS WITH ANKYLOSING SPONDYLITIS
D. A. Poddubnyy, A. P. Rebrov.Hospital Therapy Department, Saratov State Medical University, Saratov, Russian Federation

Background: Endothelial dysfunction is an imbalance between production of vasodilating, anticoagulant, anti-inflammatory factors (NO, prostacyclin, natriuretic factor etc.) and vasoconstrictive, procoagulant, proinflammatory factors (endothelin-1, thromboxane A2, von Willebrand factor, etc). Decreased NO production and increased endothelin-1 production are the main non-hemodynamic factors of left ventricle hypertrophy progression.⁴⁵ Furthermore endothelial dysfunction (particularly NO deficiency) plays an important role in progression of pulmonary hypertension.² Chronic systemic inflammation can affect endothelium and leads to endothelial dysfunction. This phenomenon is well described in rheumatoid arthritis and systemic lupus erythematosus¹³ and there is some evidence of endothelial dysfunction presence in ankylosing spondylitis (AS).

Objective: Assessment of endothelial dysfunction influence on myocardial remodeling in patients with AS.

Materials and methods: 86 patients (84 men and 2 women) with reliable AS due to modified New York criteria diagnosis of AS . . . [Full text of this article]