EDITORIAL
Microangiopathic antiphospholipid syndrome
Is there a microangiopathic antiphospholipid syndrome?
1 Division of Immunology, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa
2 Division of Rheumatology, University of Texas, Galveston, Texas, USA
3 Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain
Correspondence to:
Correspondence to:
Professor Ronald A Asherson
Division of Immunology, School of Pathology, University of the Witwatersrand and the Rosebank Clinic, Johannesburg 2196, South Africa; ashron@icon.co.za
Accepted 25 January 2007
Revealing the evolution of the term APS and its commonalities with other microangiopathic disorders
| The first 150 words of the full text of this article appear below. |
The occurrence of small-vessel occlusions (thrombotic microangiopathy) in association with anti-phospholipid antibodies (aPL) affecting, for example, the retinal vessels,1 the nail fold,2,3 the skin,4 or major intrabdominal organs such as the kidney, the liver or the bowel,5 although uncommon, is well documented. These occlusions have been described in the simple or classic antiphospholipid syndrome (APS), whether or not associated with systemic lupus erythematosus (SLE), or in the primary APS,6 but they do not in any way dominate the clinical picture in these conditions. However, with the description and definition of the catastrophic APS (also known as Asherson’s syndrome) in 19927,8 (a new subset of the APS, often fatal, with many distinguishing characteristics separating it from the simple APS),9–11 there has been renewed interest in the thrombotic microangiopathies and their association with aPL. Although large-vessel occlusions do occur in catastrophic APS, they do not dominate the clinical picture,
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