EDITORIAL
Sjögren's syndrome
Lymphoma and other malignancies in primary Sjögren’s syndrome
Correspondence to:
Correspondence to:
Dr S R Pillemer
Clinical Development, Immunological and Inflammatory Diseases, MedImmune, Inc, One Medimmune Way, Gaithersburg, Maryland 20878, USA; pillemers@medimmune.com
Accepted 16 February 2006
Low peripheral CD4+ counts or low CD4+/CD8+ ratios may be important risk factors for lymphoma in SS
Keywords: B cell lymphoma; malignancy; primary Sjögren’s syndrome cohort study; predictors
| The first 150 words of the full text of this article appear below. |
Theander et al break new ground with the observation that a low CD4+/CD8+ T lymphocyte ratio is a risk factor for the development of B cell lymphoma in Sjögren’s syndrome (SS) in a longitudinal population based study.1 Also, while the incidence of lymphoma is substantially increased in their patients with SS over that in the general population, it is not as high that described in an initial report in a highly selected population. This increased risk of developing lymphoma was seen only in patients who met the American European classification criteria (AECC) for SS.2 Additionally, Theander et al found that purpura or skin vasculitis, and low C3 and low C4 are associated with the development of haematological malignancy.1 Interestingly, while indolent lymphomas (often of the mucosa associated lymphoid tissue (MALT) type) are more commonly reported in SS, Theander et al found that 58% in their cohort had high
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