EDITORIAL
Osteoarthritis linkage scan
Osteoarthritis linkage scan: more loci for the geneticists to investigate
Correspondence to:
Correspondence to:
J Loughlin
Institute of Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Oxford OX3 7LD, UK;john.loughlin@ndos.ox.ac.uk
Accepted 15 May 2006
Chromosomal loci potentially harbour osteoarthritis susceptibility genes, as shown by a genomewide linkage scan
| The first 150 words of the full text of this article appear below. |
Those investigating the molecular genetic basis of osteoarthritis must believe that all the hard work is beginning to reap rewards, as yet another linkage scan shows several interesting chromosomal loci potentially harbouring osteoarthritis susceptibility. In the September issue of the Annals of Rheumatic Diseases, Greig et al1 reported the results of a comprehensive genomewide linkage scan performed on 202 families that contain individuals with nodal osteoarthritis, recruited from Nottinghamshire, UK.1 By using both a qualitative analysis (presence or absence of nodal osteoarthritis) and a quantitative analysis (severity of the disease), major hits were reported for chromosomes 3, 4, 8, 11 and 16. Intriguingly, the chromosome 3 and 16 hits overlap with osteoarthritis loci reported by other groups, implying that at least these two linkages are likely to be genuine.
So how does this latest linkage data fit in with what we currently know about the molecular
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- Linkage to nodal osteoarthritis: quantitative and qualitative analyses of data from a whole-genome screen identify trait-dependent susceptibility loci
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Ann Rheum Dis 2006 65: 1131-1138.[Abstract] [Full Text] [PDF]
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