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Yet more evidence that osteoarthritis is not a cartilage disease

¹ Indiana University School of Medicine, Indianapolis, USA
² Tufts University School of Medicine, Boston, USA
³ University of Bristol, Bristol, UK
⁴ University of Nijmegen, Nijmegen, The Netherlands

Correspondence to:
Correspondence to:
K D Brandt
Indiana University School of Medicine, 8829 Rexford Road, IN 46260, USA; kenbrandt1@comcast.net

Accepted 17 July 2006

The first 150 words of the full text of this article appear below.

In this issue of the Annals of Rheumatic Diseases, Tan et al¹ report the results of high-resolution magnetic resonance imaging (hrMRI) of interphalangeal joints of 20 subjects who had "clinically osteoarthritic" and painful finger joints for <l year. The MRI observations are supported by histological and radiographic examination of dissecting room specimens of apparently non-arthritic interphalangeal joints from three elderly people, and are an extension of earlier work by the same group of investigators.² Their findings indicate that structural changes in the collateral ligaments of the interphalangeal joints were uniformly present even when the articular cartilage appeared normal. The authors concluded that " ... the role of ligaments as an initiating or perpetuating factor in the pathogenesis of non-traumatic knee and hip disease merits attention. The damage evident within the small joint collateral ligaments raises the possibility that this is the principal site . . . [Full text of this article]

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