© 2005 by BMJ Publishing Group Ltd & European League Against Rheumatism
LEADER
Inflammatory arthritis
Benefit of pregnancy in inflammatory arthritis
1 Laboratory of Experimental Rheumatology and Neuroendocrinoimmunology, Division of Rheumatology, Department of Internal Medicine I, University Hospital Regensburg, Germany
2 Department of Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany
3 Division of Rheumatology, Department of Internal Medicine and Medical Specialties, San Martino University Hospital, Genova, Italy
Correspondence to:
Correspondence to:
Professor R H Straub
Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital, 93042 Regensburg; rainer.straub@klinik.uni-regensburg.de
Pregnancy related hormones provide an anti-inflammatory milieu
Keywords: cytokines; immune response; pregnancy; rheumatic disease
| The first 150 words of the full text of this article appear below. |
Observations in the 19th century (Trousseau 1871, Charcot 1881, Bannatyne 1896) indicated that pregnancy is favourable in rheumatoid arthritis (RA). This was summarised in the Nobel Prize lecture of the rheumatologist Philip S Hench, 11 December 1950 (http://nobelprize.org/medicine/laureates/1950/hench-lecture.pdf, accessed 5 April 2005). This intriguing finding stimulated clinical and basic research into endocrine immune interactions and gender studies in rheumatic diseases, particularly in RA and systemic lupus erythematosus (SLE).
Philip S Hench wrote: "...after 1931, records of these cases (of cases with RA) were more carefully made and assembled ... because of my growing belief that this phenomenon of relief (from arthritic disability) was analogous to, if not identical with, that which may occur during jaundice, and that the same agent might be responsible for the relief both during pregnancy and jaundice, although the mechanism ... might be different."1
Until today, the sole and only factor during
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This article has been cited by other articles:
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Gayed, M., Gordon, C.
(2007). Pregnancy and rheumatic diseases. Rheumatology (Oxford)
46: 1634-1640
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