Annals of the Rheumatic Diseases 2005;64:1529-1531
EDITORIAL
Rheumatoid arthritis
Will our current success in treating rheumatoid arthritis hinder new drug development? That is the question!!
Correspondence to:
Dr M E Weinblatt
Brigham and Women’s Hospital, 75 Francis Street, Boston, MA 02115, USA; mweinblatt@partners.org
Accepted 22 August 2005
This remains a problem—suggestions from colleagues welcome!
Keywords: clinical trials; rheumatoid arthritis
| The first 150 words of the full text of this article appear below. |
Who would have thought 10 years or even 5 years ago that our current success in treating rheumatoid arthritis (RA) could have an adverse effect on future drug development? Even a decade ago this question would have been considered moot owing to the limited number of effective treatments available then for RA. Since that time therapeutic advances have made a substantial impact on the ability to control this disease.
To understand the problems that we now face in drug development in RA it is important to look back and see how far we have progressed over the past 20 years. In 1985 many rheumatologists considered RA to be a slowly progressing disease, one in which radiographic damage required years to become evident. The approach to treatment was the "pyramid" concept: a sedate escalation from aspirin and non-steroidal anti-inflammatory drugs (NSAIDs), then to corticosteroids, and finally, the eventual introduction
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