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Refractory leg infection as an inducer of the catastrophic antiphospholipid syndrome

¹ Rheumatology Unit, Hadassah Medical Centre, Ein-Karem, PO Box 12000, Jerusalem 91120, Israel

Correspondence to:
Correspondence to:
Dr H Amital
amitalh@netvision.net.il

Keywords: anticardiolipin antibodies; antiphospholipid syndrome; gangrene; infection

The first 150 words of the full text of this article appear below.

In their report Yoo et al describe a 72 year old woman who presented with fever and symmetrical gangrene of the fingers and toes despite intact peripheral arterial pulses.¹Klebsiella pneumoniae grew both from blood and liver biopsy aspirates. Treatment with antibiotics, prostacyclin, tissue plasminogen activator followed by warfarin and aspirin was beneficial and led to the regression of almost all the lesions. The authors state that "Although Amital et al reported that amputation could induce remission of the systemic illness, some reports have recommended that non-surgical management is preferable if there is an intact pulse in the affected limb".

The term "catastrophic" antiphospholipid syndrome (CAPS) is used to define an accelerated form of antiphospholipid syndrome (APS) resulting in multiorgan failure. These patients have clinical evidence of multiple organ involvement, which develops within a short period of time, in addition to histopathological evidence of multiple small vessel thrombotic occlusion and . . . [Full text of this article]

J-H Yoo ², J-K Min ², S-S Kwon ², W-S Shin ², C-H Jeong ³

² Department of Internal Medicine, Holy Family Hospital, The Catholic University of Korea, College of Medicine, Seoul, Korea
³ Department of Orthopaedic Surgery, Holy Family Hospital, The Catholic University of Korea, College of Medicine, Seoul, Korea

Correspondence to:
Correspondence to:
Professor J-H Yoo
mogulkor@medimail.co.kr