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Sjögren's syndrome

Central nervous system involvement in Sjögren’s syndrome

F C Soliotis, C P Mavragani, H M Moutsopoulos

Department of Pathophysiology, School of Medicine, National University of Athens, Greece

Correspondence to:
Correspondence to:
Professor H M Moutsopoulos
Department of Pathophysiology, Medical School, University of Athens, 75 M Asias, 115 27, Athens, Greece; hmoutsop@med.uoa.gr

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Still an unresolved issue—multicentre studies are needed

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Keywords: Sjögren’s syndrome; central nervous system disease; vasculitis

The first 150 words of the full text of this article appear below.

Sjögren’s syndrome (SS) is a relatively common autoimmune disorder, affecting 2–3% of the adult population. It is characterised by lymphocytic infiltration and destruction of the exocrine glands. The salivary and lachrymal glands are primarily affected, leading to a dry mouth and dry eyes, the hallmark of the disease. Other exocrine glands, which may be affected, include those of the pancreas, bronchial tree, and gastrointestinal tract. SS may occur alone (primary) or in association with other connective tissue diseases (secondary). The spectrum of clinical manifestations of SS is wide, ranging from mucosal dryness, directly related to exocrine dysfunction, to more systemic complaints, affecting mainly the musculoskeletal, pulmonary, renal, and vascular systems.¹ Peripheral nervous system disease, manifested commonly as peripheral sensory neuropathy or more rarely as mononeuritis multiplex, is a well established feature of the disease, occurring in approximately a quarter of patients.² However, involvement of the central nervous system . . . [Full text of this article]

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