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Lupus nephritis
Lupus nephritis: current issues
H M Moutsopoulos, Department of Pathophysiology, School of Medicine, National University of Athens, Greece
Correspondence to:
Correspondence to:
Professor H M Moutsopoulos, Department of Pathophysiology, Medical School, University of Athens, 75 M Asias Street, 115 27 Athens, Greece;
hmoutsop@med.uoa.gr
The best approach to treatment of renal disease in systemic lupus erythematosus remains unresolved
Keywords: cytotoxicity; glomerulonephritis; immunosuppressive drugs; toxicities
| The first 150 words of the full text of this article appear below. |
Systemic lupus erythematosus (SLE), the prototype of systemic autoimmune disorders, has been considered for many years a classic model of immune complex mediated disease. However, earlier data demonstrate that multilevel dysfunction of cellular and humoral immunity underlie the pathophysiology of the disorder.1,2 The expression and clinical course of SLE vary enormously from very mild, with arthralgias and skin rashes, to life threatening, when the renal and central nervous system function are severely compromised; from complete quiescence to full blown expression of the disease. Coexistence or even evolution into other types of autoimmune disorders, such as Sjögren’s syndrome and mixed connective tissue disease can also occur. Finally, subsets of SLE were early recognised: distinct clinical entities such as antiphospholipid syndrome (APS) or subacute lupus erythematosus are considered to be part of the "SLE" clinical spectrum.1
Among the various organs affected in SLE, the kidney appears to be one of
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This article has been cited by other articles:
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Masood, S, Jayne, D, Karim, Y
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18: 106-115
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