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Rheumatoid arthritis

Circadian rhythms in RA

M Cutolo, B Seriolo, C Craviotto, C Pizzorni, A Sulli

Research Laboratory and Division of Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV,6 16132 Genova, Italy Correspondence to: Professor M Cutolo; mcutolo@unige.it

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Possible roles of cortisol and melatonin

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Keywords: circadian rhythms; cortisol; cytokines; melatonin; rheumatoid arthritis

The first 150 words of the full text of this article appear below.

It is well known that some clinical signs and symptoms of rheumatoid arthritis (RA) vary within a day and between days, and the morning stiffness seen in patients with RA has become one of the diagnostic criteria of the disease (fig 1).¹

View larger version (11K): [in this window] [in a new window]   Figure 1 Clinical signs and symptoms of articular inflammation in patients with RA change consistently as a function of the hours of the day: pain and joint stiffness are greater after waking up in the morning than in the afternoon or evening.

 

Among the clinical signs of joint inflammation in patients with RA, the intensity of pain changes consistently as a function of the hours of the day: pain is greater after waking up in the morning than in the afternoon or evening.² In patients with RA circadian variations are also found in joint swelling and finger size and these symptoms are in phase with the circadian . . . [Full text of this article]

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• Jessop, D. S., Harbuz, M. S. (2005). A defect in cortisol production in rheumatoid arthritis: why are we still looking?. Rheumatology (Oxford) 44: 1097-1100 [Full Text]  
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Melatonin suppression may not be a promising therapeutic option for the treatment of RA

Robert Eli

Ann Rheum Dis Online, 2 Aug 2005 [Full text]