© 2003 by BMJ Publishing Group & European League Against Rheumatism
LEADER
Osteoarthritis
Chondrocalcinosis, osteophytes and osteoarthritis
Indiana University School of Medicine; Indiana University Multipurpose Arthritis and Musculoskeletal Diseases Center, 1110 West Michigan Street, Room 545, Indianapolis IN 46202, USA
Correspondence to:
Correspondence to:
Professor K D Brandt;
kbrandt@iupui.edu
Crystals, spurs, and osteoarthritis
Keywords: chondrocalcinosis; community; osteoarthritis; diuretics; calcium pyrophosphate
| The first 150 words of the full text of this article appear below. |
An association between osteoarthritis (OA) and radiographic evidence of chondrocalcinosis (CC) has been recognised for years. Crystals of calcium pyrophosphate dihydrate (CPPD) may be found in synovial fluid from patients with OA who are relatively asymptomatic as well as from those who are experiencing an acute flare up of joint pain due to an attack of pseudogout. Whether CC is the cause of OA in such people or develops as a result of changes in metabolism of the chondrocyte or in the extracellular matrix of the articular cartilage is unclear. In any event, conditions associated with CC, such as hyperparathyroidism, Wilson’s disease, and haemochromatosis, are well recognised causes of "secondary" OA.1
Chondrocytes from patients with OA who do not exhibit CC produce as much pyrophosphate as those from the cartilage of patients with CPPD disease.2 Furthermore, chondrocytes from human OA cartilage exhibit increased sensitivity to transforming growth factor ß
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