© 2003 by BMJ Publishing Group & European League Against Rheumatism
LEADER
Hypouricaemia
Fenofibrate and losartan
Fédération de Rhumatologie, Hôpital lariboisiére, 2 rue Ambroise Paré, 75010 Paris, France
Correspondence to:
Correspondence to:
Professor T Bardin;
thomas.bardin@lrb.ap-hop-paris.fr
Should we take advantage of their uricosuric properties in clinical practice?
Keywords: losartan; fenofibrate; uric acid; hypertension; hypertriglyceridaemia
| The first 150 words of the full text of this article appear below. |
The interesting study published in this issue of the journal by Takahashi et al sheds light on two drugs, losartan and fenofibrate, which have hypouricaemic properties, in addition to their main therapeutic effects.1
Losartan potassium is an orally active angiotensin II receptor antagonist used for the treatment of hypertension. This product and its long life metabolite E-3174 are potent antagonists at the AT1 receptor. The observation that losartan increases urinary uric acid excretion and reduces serum uric acid level was first made in a pilot study conducted in healthy subjects and published in 1992. Uric acid fractional clearance was mainly increased during the first four hours after drug intake in a time course consistent with a direct effect of the drug. The increase was found to be dose dependent and to persist after seven days of administration.2 Angiotensin is known to lower uric acid renal clearance,3 but the uricosuric
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This article has been cited by other articles:
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Daskalopoulou, S S, Mikhailidis, D P, Athyros, V G, Papageorgiou, A A, Elisaf, M
(2004). Fenofibrate and losartan. Ann Rheum Dis
63: 469-470
[Full Text] -
(2003). Robin Goodfellow (42-8). Rheumatology (Oxford)
42: 1028-1028
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