© 2003 by BMJ Publishing Group Ltd & European League Against Rheumatism
LEADER
Osteoarthritis
Early stages of osteoarthritis: the search for sensitive predictors
Correspondence to:
Correspondence to:
F A Wollheim, Department of Rheumatology, University of Lund Hospital, S-221 85 Lund, Sweden;
Frank.Wollheim@reum.lu.se
Risk factors, standard radiography, and biomarkers can be used to detect pre-OA
| The first 150 words of the full text of this article appear below. |
Osteoarthritis (OA) is perhaps the most common disabling joint affection in developed countries, and consequently a large burden to their health systems.1 Furthermore, it is a growing global problem due to increasing life expectancy as well as obesity and smoking, all identified as risk factors for developing knee OA and knee pain.2,3 Efforts to identify early stages of knee OA are gaining importance because of its prevalence and morbidity and the possible emergence of preventive or modifying interventions. However, radiographic delineation of OA at its onset is not a trivial problem as highlighted by the careful study of Mazzuca et al in this issue of the journal.4 In essence the paper shows that radiographically normal is not identical to anatomically normal. Thus the designation of the unilateral nature of knee OA in the Chingford study is not strictly correct.15 Nevertheless, the Chingford approach to studying early phases of progression
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