Register for email alerts and news feeds:
This journal | BMJ Group
rss
Annals of the Rheumatic Diseases 2002;61(Supplement 2 ):29; doi:10.1136/ard.61.suppl_2.ii29
Copyright © 2002 BMJ Publishing Group Ltd & European League Against Rheumatism.
Annals of the Rheumatic Diseases 2002;61:ii29-ii31
© 2002 by Annals of the Rheumatic Diseases

REPORT

Mesenchymal stem cells. A potential source for skeletal repair

W E Fibbe

Laboratory of Experimental Haematology, Department of Haematology, Leiden University Medical Centre, Leiden, Netherlands

Correspondence to:
Correspondence to:
Dr W E Fibbe, Department of Haematology, Leiden University Medical Centre, Location C2R – Room 137, 2333 AA Leiden, Netherlands;
W.E.Fibbe@LUMC.nl

Keywords: mesenchymal stem cells; skeletal repair

Abbreviations: MSC, mesenchymal stem cell; CFU-F, colony forming unit fibroblastic

The first 150 words of the full text of this article appear below.

The bone marrow serves as a reservoir for different classes of stem cells. In addtion to haematopoietic stem cells the bone marrow comprises a population of marrow stromal cells or mesenchymal stem cells (MSCs). Stromal cells exhibit multilineage differentiation capacity, and are able to generate progenitors with restricted developmental potential, including fibroblasts, osteoblasts, adipocytes, and chondrocyte progenitors.1–3

Recently, techniques have become available to isolate and grow mesenchymal progenitors and to manipulate their growth under defined in vitro culture conditions. As a result MSCs can be rapidly expanded to numbers that are required for clinical application. Here the role of MSCs for repair of bone and cartilage is discussed.

MARROW STROMAL CELLS

Marrow stromal cells comprise a heterogenous population of cells, including reticular endothelial cells, fibroblasts, adipocytes, and osteogenic precursor cells that provide growth factors, cell to cell interactions, and matrix proteins that play a part in the regulation of haematopoiesis.4–6 The notion that . . . [Full text of this article]


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

This article has been cited by other articles:

  • Abdi, R., Fiorina, P., Adra, C. N., Atkinson, M., Sayegh, M. H. (2008). Immunomodulation by Mesenchymal Stem Cells: A Potential Therapeutic Strategy for Type 1 Diabetes. Diabetes 57: 1759-1767 [Abstract] [Full Text]  
  • Liu, H., Kemeny, D. M., Heng, B. C., Ouyang, H. W., Melendez, A. J., Cao, T. (2006). The immunogenicity and immunomodulatory function of osteogenic cells differentiated from mesenchymal stem cells.. J. Immunol. 176: 2864-2871 [Abstract] [Full Text]  

This Article

Services
Citing Articles
Google Scholar
PubMed
Bookmark with

Register for free content

The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

BMJ Careers - Latest Rheumatology Jobs

Rheumatology Jobs