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Mesenchymal stem cells. A potential source for skeletal repair

Laboratory of Experimental Haematology, Department of Haematology, Leiden University Medical Centre, Leiden, Netherlands

Correspondence to:
Correspondence to:
Dr W E Fibbe, Department of Haematology, Leiden University Medical Centre, Location C2R – Room 137, 2333 AA Leiden, Netherlands;
W.E.Fibbe@LUMC.nl

Keywords: mesenchymal stem cells; skeletal repair

Abbreviations: MSC, mesenchymal stem cell; CFU-F, colony forming unit fibroblastic

The first 150 words of the full text of this article appear below.

The bone marrow serves as a reservoir for different classes of stem cells. In addtion to haematopoietic stem cells the bone marrow comprises a population of marrow stromal cells or mesenchymal stem cells (MSCs). Stromal cells exhibit multilineage differentiation capacity, and are able to generate progenitors with restricted developmental potential, including fibroblasts, osteoblasts, adipocytes, and chondrocyte progenitors.^1–3

Recently, techniques have become available to isolate and grow mesenchymal progenitors and to manipulate their growth under defined in vitro culture conditions. As a result MSCs can be rapidly expanded to numbers that are required for clinical application. Here the role of MSCs for repair of bone and cartilage is discussed.

MARROW STROMAL CELLS
Marrow stromal cells comprise a heterogenous population of cells, including reticular endothelial cells, fibroblasts, adipocytes, and osteogenic precursor cells that provide growth factors, cell to cell interactions, and matrix proteins that play a part in the regulation of haematopoiesis.^4–6 The notion that . . . [Full text of this article]

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