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PREFACE |
1 University of Leiden
2 University of Erlangen
3 University of Vienna
Keywords: tumour necrosis factor 
| The first 150 words of the full text of this article appear below. |
The papers brought together in this supplement of the Annals of the Rheumatic Diseases constitute summaries of presentations at the Fourth International Symposium on Advances in Targeted Therapies which was held in April/May 2002. As such, these presentations represent the state of the art on the biology of mechanisms of action and pathophysiology of tumour necrosis factor (TNF) and interleukin (IL1) as well as other important mediators of inflammation. Current knowledge on the means and consequences of blocking TNF, IL1, or other molecules is presented as well.
We are grateful to Drs Crofford, Feldmann, Furst, Klareskog, Lipsky, Maini, Moreland, and Weinblatt, the members of the advisory board of the symposium, for their invaluable help towards the success of the conference, the fourth of a series of similar events planned for the future. We particularly wish to thank all speakers for their excellent presentations, most of which are summarised here in
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