© 2002 by Annals of the Rheumatic Diseases
LEADER
Rheumatoid arthritis
Vaccination and rheumatoid arthritis
1 Department of Rheumatology, Strasbourg University Hospital, France
2 Department of Rheumatology, Dijon University Hospital, France
Correspondence to:
Correspondence to:
Dr J Sibilia, Department of Rheumatology, Hôf.pital Hautepierre, Avenue Moliére, 67098 Strasbourg, France;
jean.sibilia@wanadoo.fr
Induction of rheumatoid arthritis by vaccination against hepatitis B—myth or reality?
Keywords: hepatitis B vaccine; adverse effects; arthritis; rheumatoid arthritis
| The first 150 words of the full text of this article appear below. |
Recently, medical and public interest in the safety of vaccination, particularly against hepatitis B, has been heightened by reports in medical journals and in the media of possible adverse effects, especially of suspected vaccination-induced autoimmune disorders. Although these suspected effects most commonly belong to the neurological area, a number of authors have published cases of rheumatic disease, notably rheumatoid arthritis (RA), following hepatitis B vaccination.1–10 This editorial does not aim to review the relationship between vaccination and autoimmune disorders, which has already been discussed in several recent and interesting papers,11–13 but to centre the discussion on the possible connection between hepatitis B vaccination and RA.
The rheumatic disorders described following hepatitis B vaccination are heterogeneous but can be divided into three groups. Firstly, transient conditions such as vasculitis, post-vaccinal arthritis or erythema nodosum might be due to the deposition of immune complexes containing viral antigen and anti-hepatitis B
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