Review
Stem cells for repair of cartilage and bone: the next challenge in osteoarthritis and rheumatoid arthritis
C Jorgensena b, D Noelb, F Apparaillyb, J Sanya ba Service
d'Immuno- Rhumatologie, Hôpital Lapeyronie, 34295 Montpellier
cedex 5, France, b INSERM U475, 99 rue Puech Villa, 34197 Montpellier cedex 5, France
Correspondence to: Dr Jorgensen, Service d'Immuno-Rhumatologie, CHU Lapeyronie, 371 avenue du Doyen Gaston Giraud, 34295 Montpellier cedex 5, France jorgens@montp.inserm.fr
Accepted for publication 9 August
2000
| The first 150 words of the full text of this article appear below. |
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Introduction |
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Over the last few years, immunotherapy targeting proinflammatory cytokines has been the main goal of research into rheumatoid arthritis (RA), and recently the new anti-(tumour necrosis factor) blocking agents have dramatically improved the course of the disease by stabilising the symptoms.1 However, this treatment has no effect on regeneration of articular cartilage damaged during the inflammatory process. The next challenge is thus to ensure cartilage repair through cell therapy and tissue engineering (fig 1). Tissue in the body is replaced by two main mechanisms. One is self repair by fully differentiated cells (healing), and the second is replacement with newly differentiated cells derived from stem cells. Recently, the regenerative potential of mesenchymal stem cells (MSCs) has been under intense investigation because of their ability for self renewal and differentiation to reconstitute muscle, cartilage, or bone.2
| Figure Removed (Available Only in the Full Text) |
Articular cartilage is a complex tissue consisting of cartilage matrix
and the chondrocytes that
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