Review
Behçet's disease and thrombophilia
M Leibaa, Y Sidia, H Gura, A Leibaa, M Ehrenfelda ba Department of
Medicine "C", Sheba Medical Centre, Tel-Hashomer, and Sackler
Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, b Rheumatic Disease Unit, Sheba Medical Centre,
Tel-Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel
Aviv, Israel
Correspondence to: Dr M Ehrenfeld, Department of Internal Medicine "C", Sheba Medical Centre, Tel-Hashomer 52621, Israel ehrenfel@post.tau.ac.il
Accepted for publication 14 May 2001
| The first 150 words of the full text of this article appear below. |
 |
Introduction |
|---|
Behçet's disease (BD), first described in 1973, is characterised by recurrent oral and genital ulcers as well as eye inflammation. Other features of this chronic multisystem inflammatory disease include neurological, cardiovascular, pulmonary, gastrointestinal, musculoskeletal, and dermatological involvement.1
Venous or arterial thrombosis occurs in 25% (10-37%) of patients.2 Venous thrombosis is more common than arterial thrombosis (88% v 12%).3 Deep and superficial venous thrombosis of the legs predominates.4-7
Arteritis is treated with a combination of corticosteroids and cytotoxic agents. Anticoagulants and antiplatelet agents are used for deep venous thrombosis, though there has never been a properly controlled study to justify this treatment in BD.8
The thrombin-antithrombin complex (TAT) is a marker of intravascular thrombin formation. Prothrombin fragments 1+2 (PF1.2) are peptide fragments generated when prothrombin is activated to thrombin. TAT and PF1.2 are both biological markers of thrombin generation and thus correlate with thrombotic risk.9 10
Several studies have shown increased levels of
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Leiba, M, Seligsohn, U, Sidi, Y, Harats, D, Sela, B A, Griffin, J H, Livneh, A, Rosenberg, N, Gelernter, I, Gur, H, Ehrenfeld, M
(2004). Thrombophilic factors are not the leading cause of thrombosis in Behcet's disease. Ann Rheum Dis
63: 1445-1449
[Abstract] [Full Text] -
Zouboulis, C C, Kaklamanis, P
(2003). Early descriptions of Adamantiades-Behcet's disease. Ann Rheum Dis
62: 691-692
[Full Text] -
Ehrlich, G E, Leiba, M, Sidi, Y, Gur, H, Leiba, A, Ehrenfeld, M
(2002). Behcet's disease and thrombophilia. Ann Rheum Dis
61: 381-381
[Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
