Ann Rheum Dis 2000;59(Suppl 1):i28-i31 ( November )

Clinical outcome measures in rheumatoid arthritis

Piet L C M van Riel, Anke M van Gestel

University Medical Centre Nijmegen, Department of Rheumatology, Geert Grooteplein 8, 6525 GA Nijmegen, the Netherlands

Correspondence to: Professor van Riel, (P.vanRiel@reuma.azn.nl)

The first 150 words of the full text of this article appear below.

	Introduction

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease with peripheral synovitis as its main manifestation. The presentation of the disease and the course during time are highly variable both within as well as between individuals.The symptoms and signs of RA may vary from joint complaints like pain, stiffness, swelling and functional impairment, to more constitutional complaints like fatigue and loss of general health. Because of this variety in disease expression a huge number of outcome variables have been used in the past decades to evaluate interventions in clinical trials.¹

Many efforts have been taken in the past years to standardise the assessment of RA aiming at making study results interchangeable. Consensus has been reached about a minimal set of disease activity variables to be measured in clinical trials.^2 3 As a following step response criteria based on these core set variables have been developed by the European League Against Rheumatism . . . [Full text of this article]

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