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Carol-Nachman prize for rheumatology
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Professors J Sieper and J Braun from Berlin have been honoured with the Carol-Nachman prize for rheumatology of the city of Wiesbaden. The Carol-Nachman prize is the most prestigious international award in rheumatology. They received the prize for their work on the role of T cell cytokines in the pathogenesis of arthritides and as a possible target of immunomodulating treatments. Sieper and Braun studied the different reactivity of T helper 1 (Th1) and Th2 lymphocytes in various forms of arthritides, including reactive arthritis, Lyme arthritis, rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis.
They found that the low Th1 response of the synovial membrane in
patients with reactive arthritis and the high Th2 response in patients
with Lyme arthritis is inadequate for an effective elimination of
bacteria and a possible cause of bacterial persistence in these
disorders. In addition, they described by flow cytometric analysis of
synovial lymphocytes a high frequency of T
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