Review
Synovial biopsy in arthritis research: five years of concerted European collaboration
Barry Bresnihana, Paul Peter Takb, Paul Emeryc, Lars Klareskogd, Ferdinand Breedvelde
a Department of
Rheumatology, St Vincents University Hospital, Dublin 4, Ireland, b Division of Clinical
Immunology and Rheumatology, Academic Medical Centre, Amsterdam, The
Netherlands, c Rheumatology
Research Unit, University of Leeds, Leeds, United Kingdom, d Rheumatology
Unit, Department of Medicine, Karolinska Hospital, Stockholm, Sweden, e Department of Rheumatology,
Leiden University Medical Centre, Leiden, The Netherlands
Correspondence to: Professor Bresnihan Email: b.bresnihan@svcpc.ie
Accepted for publication 1 May 2000
| The first 150 words of the full text of this article appear below. |
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Introduction |
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The term rheumatoid arthritis (RA) was first proposed by Garrod in 1859.1 By 1959, the histopathological features of synovitis, the proliferating pannus, and cartilage degradation in longstanding RA had been well described.2 Early histopathological studies were based on tissue samples obtained at surgery or at postmortem examinations. Occasionally, biopsy samples were obtained for analysis from patients with arthritis undergoing open arthrotomy.
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Needle biopsy of synovium |
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The initial interest in developing synovial biopsy techniques was
to aid the differential diagnosis of joint diseases. In 1932 Forestier
described a technique for obtaining synovial tissue with a dental nerve
extractor that was introduced into the joint through a large calibre
needle.3 He never published his results. Early experience
with needle biopsy of the synovium was described in the
1950s.4 5 It was concluded that if strict aseptic techniques were employed, the procedure was safe and practical for use
in both hospital wards and outpatient clinics. However, the biopsy
needles tended
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